CD62E (SELE) (+CD62P) Mouse Monoclonal Antibody [Clone ID: 1.2B6]

CAT#: BM311F

CD62E (SELE) (+CD62P) mouse monoclonal antibody, clone 1.2B6, FITC


USD 415.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 1.2B6
Applications FC
Recommended Dilution Flow Cytometry: Use 10µl of neat antibody to label 1 x 10e6 cells in 100µl.
Reactivities Human, Porcine
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human E-Selectin (ELAM-1).
Spleen cells from immunised BALB/c mice were fused with cells of the NS1 mouse myeloma cell line.
Specificity This antibody recognizes the CD62E and CD62P cell surface antigens. Although previously thought to recognise only Human CD62E, recent data (Goda et al. 2003) shows that this antibody also recognizes Human CD62P, binding to a common epitope shared by these members of the selectin family.
Formulation PBS, pH 7.4
Label: FITC
State: Liquid purified IgG fraction from Tissue Culture Supernatant
Stabilizer: 1% BSA
Preservative: 0.09% Sodium Azide
Label: Fluorescein Isothiocyanate Isomer 1
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation FITC
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens selectin E (SELE)
Background CD62E is also known as endothelial leukocyte adhesion molecule 1 (ELAM1) or E selectin. It is a type I membrane protein that belongs to the selectin family of surface molecules (along with CD62L and CD62P). Selectins are C type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. CD62E (E selectin) is an endothelial cell specific selectin that is expressed on cytokine induced endothelial cells only after activation with proinflammatory cytokines. In vitro experiments have shown that IL1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of CD62E in an NFkB dependent signalling cascade. CD62E has been associated with blood vessel endothelium in diverse inflammatory situations. The main ligands recognised by CD62E are oligosaccharides related to sialyl lewis x.
Synonyms SELE, ELAM1, LECAM2
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.