Cardiotin Mouse Monoclonal Antibody [Clone ID: SR-3]
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Product Data | |
Clone Name | SR-3 |
Applications | IHC, WB |
Recommended Dilution | Immunoblotting. Immunohistochemistry on Frozen Sections. Recommended Dilutions: 1/100–1/200 for Immunohistochemistry with ABC as detection reagent and 1/100–1/500 for Immunoblotting. |
Reactivities | Human, Porcine |
Host | Mouse |
Isotype | IgM |
Clonality | Monoclonal |
Immunogen | 100 kDa Cardiotin subunit. |
Specificity | This antibody SR-3 reacts with Cardiotin, a mitochondrion-associated protein, which is present in cardiomyocytes and skeletal muscle, but also in epithelial cells and tissues. In immunoblotting assays SR-3 recognizes the 300 kDa cardiotin protein complex and its 100 kDa and 60 kDa subunits. |
Formulation | PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide |
Concentration | 1.0 mg/ml |
Background | Cardiotin is a high molecular weight protein complex (300 kDa) located in the mitochondria of cardiomyocytes and skeletal muscle. The cardiotin structure exists of subunits of 60 kDa and 100 kDa, probably in a tetrameric configuration. Both subunits contain the same amino-terminal 14 amino-acid sequence, showing high homology to human skeletal muscle α-actinin. During cardiac contractile dysfunction and myocard cell differentiation, the cardiotin distribution is affected. Compared to other structural proteins, cardiotin is one of the first to respond to insults (ischemia, fibrillation) that influence the functional status of cardiomyocytes. |
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