CX3CR1 (Extracell. Loop V28) Rabbit Polyclonal Antibody

CAT#: BP2209

CX3CR1 (Extracell. Loop V28) rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Can be used for detection of CX3CR1 by Western blot (1/500). THP-1 cell lysate can be used as positive control and ~50 kDa band can be detected.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide corresponding to amino acids 175-189 of human CX3CR1 by one amino acid (3, 4).
• Specificity: It is Human reactive.
• Formulation: PBS containing 0.02% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Purification: Immunoaffinity chromatography .
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Should this product contain a precipitate we recommend microcentrifugation before use.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 1524 Human
• Background: CX3CR1 is one of the chemokine receptors that are required as co-receptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion and has been implicated in tumor metastasis. CX3CR1 is expressed in a variety of human tissues and cell lines.
• Synonyms: CX3C chemokine receptor 1, C-X3-C CKR-1,CMKBRL1, CMK-BRL-1