Cd207 Rat Monoclonal Antibody [Clone ID: 918A11]

CAT#: DDX0376P-100

Cd207 rat monoclonal antibody, clone 918A11

Product Images

IF staining of mock (left) and Langerin (right) transfected COP5 cells

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  IF staining of mouse epiderm (ear) frozen section with clone 918A11 (DX0376)

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  Surface FACS staining of Langerin transfected COP5 cells

Specifications

Product Data

• Clone Name: 918A11
• Applications: FC, IF, IHC
• Recommended Dilution: FACS surface, ImmunoFluorescence, ImmunoHistoChemistry frozen sections.
  
  Usage recommendation:
  *This monoclonal antibody may be used between 5-20 μg/ml.
  *Optimal dilution should be determined by each laboratory for each application.
  *Coupled antibody: to maintain RT before use.
  
• Reactivities: Human, Mouse, Rat
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human Langerin-transfected eukaryotic cells.
• Specificity: Human Langerin.
  Species cross-reactivity: Rat, Mouse.
• Formulation: Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
  Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol.
  State: Purified
• Concentration: lot specific
• Purification: QMA Hyper D ion exchange chromatography
• Conjugation: Unconjugated
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
  Coupled antibodies: glycerol protects from freezing.
• Gene Name: CD207 antigen
• Database Link:
  Entrez Gene 246278 Mouse
  UniProt ID Q8VBX4
• Background: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck’s granule. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin expression has not been reported outside the DC system. Human Langerin is involved in the processing of mycobacterial glycolipids leading to antigen presentation to CD1a-restricted T cells. Human Langerin binds the gp120 of HIV.
  (Valladeau J et al, 2002 J. Immunol, 168 : 782-792; Douillard P et al, 2005 J Invest Dermatol, 125: 983–994; Chorro L. et al, J Exp.Med., 2010, 206 (13), 3089-3100).
• Synonyms: CLEC4K, Dendritic Cell Marker