LYVE1 Rabbit Polyclonal Antibody

CAT#: DP3500B

LYVE1 rabbit polyclonal antibody, Biotin

Product Images

FACS analysis with Biotin conjugated LYVE-1 antibody using HDMVECs

Specifications

Product Data

• Applications: FC
• Recommended Dilution: FACS analysis and Cell Sorting: Use at 2-5 µg/ml together with the appropriate secondary reagents.
  The unconjugated antibody can be used for ELISA experiments, Western blotting, FACS and Cell Sorting.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant Human soluble LYVE-1 (Ser24-Gly232) produced in insect cells.
• Specificity: The antibody recognizes Human LYVE-1. Other species not tested.
• Formulation: 5mM PBS, pH 7.2
  Label: Biotin
  State: Lyophilized purified IgG fraction
  Stabilizer: 50x BSA
  Preservative: 0.02% Sodium Azide
• Reconstitution Method: Restore with sterile water to a concentration of 0.1-1.0 mg/ml
• Purification: Antigen Affinity Chromatography
• Conjugation: Biotin
• Database Link:
  Entrez Gene 10894 Human
• Background: LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
• Synonyms: LYVE1, CRSBP-1, CRSBP1, HAR, XLKD1