Vegfc Rabbit Polyclonal Antibody

CAT#: DP3507B

Vegfc rabbit polyclonal antibody, Biotin

Product Images

VEGF-C Sandwich-ELISA using the Biotinylated polyclonal anti-Rt VEGF-C Antibody as detection antibody and recombinant Rat VEGF-C ( DA3519X) as standard. The monoclonal mouse anti-Human VEGF-C Antibody was used as capture antibody.

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: ELISA: 1-5 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant Rat VEGF-C native protein (Asp101-Ile221) derived from insect cells (Cat.-No DA3519X)
• Specificity: The unconjugated antibody will react with Rat VEGF-C and will cross-react with Human and Mouse VEGF-C proteins.
• Formulation: 0.1M Tris, 0.2M NaCl, pH 7.2
  Label: Biotin
  State: Lyophilized purified IgG fraction
  Stabilizer: 50x BSA
  Preservative: 0.02% Sodium Azide
• Reconstitution Method: Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
• Purification: Affinity Chromatography on Protein A
• Conjugation: Biotin
• Database Link:
  Entrez Gene 114111 Rat
• Background: VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
• Synonyms: VEGFC, VRP, Vascular endothelial growth factor C, Vascular endothelial growth factor-related protein, Flt4 ligand