VEGF Receptor 2 (KDR) Rabbit Polyclonal Antibody

CAT#: DP3509B

VEGF Receptor 2 (KDR) rabbit polyclonal antibody, Biotin


USD 340.00

2 Weeks*

Size
    • 50 ug

Product Images

Specifications

Product Data
Applications ELISA, FN, IP, WB
Recommended Dilution ELISA: 5-15 μg/ml.
Western blot.
Immunoprecipitation.
Neutralizing experiments.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure recombinant human soluble extracellular domain of KDR (110 kDa)
Specificity The antibody will detect native and recombinant VEGFR-2/KDR.
Formulation PBS
Label: Biotin
State: Lyophilized Ig fraction
Stabilizer: 50x BSA
Preservative: 0.02% Sodium Azide
Reconstitution Method Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
Purification Antigen Affinity chromatography with immobilised recombinant soluble VEGFR-2/KDR
Conjugation Biotin
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Synonyms VEGFR2, FLK1, KDR, VEGF Receptor 2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.