Lyve1 Rabbit Polyclonal Antibody

CAT#: DP3513B

Lyve1 rabbit polyclonal antibody, Biotin

Specifications

Product Data

• Applications: ELISA, FC, IHC, WB
• Recommended Dilution: The unconjugated antibody can be used for ELISA (1-15 µg/ml), Western blotting (1-2 µg/ml with the appropriate secondary reagents), FACS (3-20 µg/ml together with the appropriate secondary reagents) and Cell sorting.
  The antibody is also suitable for Immunohistochemistry on Paraffin as well as on Frozen Sections (0.25-4 µg/ml).
• Reactivities: Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Highly pure recombinant Mouse soluble LYVE-1 produced in insect cells (Cat.-No DA3524).
• Specificity: This antibody detetcs Mouse and Rat Lyve-1.
  This antibody is not reactive with Human LYVE-1.
• Formulation: PBS, pH 7.4
  Label: Biotin
  State: Lyophilized purified Ig fraction
  Stabilizer: 50x BSA
  Preservative: 0.02% Sodium Azide
• Reconstitution Method: Restore with sterile water to a concentration of 0.1-1.0 μg/ml. Centrifuge vial prior to opening.
• Purification: Antigen Affinity Chromatography
• Conjugation: Biotin
• Database Link:
  Entrez Gene 114332 Mouse
• Background: LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
• Synonyms: LYVE1, CRSBP-1, CRSBP1, HAR, XLKD1