PSD95 (DLG4) Mouse Monoclonal Antibody

CAT#: MO50000-100

PSD95 (DLG4) mouse monoclonal antibody

Product Images

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  PSD-95 western blots of adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MHM) from PSD-95 knockout and WT mice (mouse samples courtesy of Dr. Richard Huganir).

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  PSD-95 (green) and Kv4.2 (red) staining of rat hippocampal neurons.

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Specifications

Product Data

• Applications: EM, IF, IHC, IP, WB
• Recommended Dilution:

  Immunofluorescence: 1:200-1:1,000
  Immunohistochemistry: 1:200-1:000
  Western Blot: 1:200-1:1000
  Immuno-gold EM
  Immunoprecipitation

• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 77-299 of human PSD-95/SAP90 (accession number P78352).
• Formulation: State: Purified
• Conjugation: Unconjugated
• Gene Name: discs large MAGUK scaffold protein 4
• Database Link:
  Entrez Gene 1742 Human
  UniProt ID P78352
• Background:

  PSD-95 or SAP90 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons,[1] and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. PSD-95 is a excellent marker for post synpatic mechanisms.

• Synonyms: DLGH4, PSD-95, Disks large homolog 4, SAP90, SAP-90