CD11b Rat Monoclonal Antibody [Clone ID: M1/70.15]
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Specifications
Product Data | |
Clone Name | M1/70.15 |
Applications | FC, FN, IHC, IP |
Recommended Dilution | Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections. Immunoprecipitation. Flow Cytometry: 1/50-1/100 (routinely tested on Mouse peritoneal macrophages). Functional Assays: Clone M1/70.15 has been reported to block iC3b binding to its receptor. Immunofluorescence. |
Reactivities | Human, Mouse, Rabbit |
Host | Rat |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | T cell enriched splenocytes from B10 mice. Spleen cells from immunised DA rats were fused with cells of the NS1/1.Ag4.1 mouse myeloma cell line. |
Specificity | This antibody recognises the CD11b cell surface antigen (also known as the alpha M integrin chain or MAC-1), a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages. |
Formulation | State: Low Endotoxin State: Liquid purified Ig fraction without preservatives. |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography on Protein G. |
Background | The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. |
Synonyms | ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1 |
Note | Endotoxin Level: < 0.01EU/µg |
Reference Data |
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