IL12B Mouse Monoclonal Antibody [Clone ID: 1-1A4]

CAT#: SM1320P

IL12B mouse monoclonal antibody, clone 1-1A4, Purified

Specifications

Product Data

• Clone Name: 1-1A4
• Applications: ELISA, IHC
• Recommended Dilution: Immunohistochemistry on frozen sections.
  ELISA: 1/1000 as detecting antibody.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant IL-12. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2-O myeloma cell line.
• Specificity: This antibody recognises the p40 subunit of interleukin-12, and binds to both the free subunit and the p35/p40 heterodimer. The antibody reacts with both stimulated and unstimulated monocytes in immunohistology.
• Formulation: PBS, pH7.4 containing 0.09% Sodium Azide
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens interleukin 12B (IL12B)
• Database Link:
  Entrez Gene 3593 Human
• Background: Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells; costimulation of PBL proliferation; proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10; homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.
• Synonyms: Interleukin-12B, IL-12B, IL-12 subunit p40, CLMF p40, NKSF2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus