CD8A Rat Monoclonal Antibody [Clone ID: YTC 182.20]
Other products for "CD8A"
Specifications
Product Data | |
Clone Name | YTC 182.20 |
Applications | FC |
Recommended Dilution | Flow cytometry: use 10 µl of neat antibody to label 10e6 cells or 100 µl whole blood. |
Reactivities | Human |
Host | Rat |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Mouse L cells transfected with human CD8 gene. Spleen cells from an immunised DA rat were fused with cells of the rat Y3/Ag.1.2.3 myeloma line. |
Specificity | This antibody recognises the CD8 cell surface antigen, a 30/32kD glycoprotein expressed by the cytotoxic/suppressor subset of T lymphocytes, and more weakly by NK cells. |
Formulation | PBS, pH7.2 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin Label: FITC State: Liquid purified IgG Label: Fluorescein Isothiocyanate Isomer 1 (FI |
Concentration | lot specific |
Conjugation | FITC |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens CD8a molecule (CD8A), transcript variant 1 |
Database Link | |
Background | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. |
Synonyms | CD8 alpha chain, CD8A, MAL |
Reference Data | |
Protein Families | Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane |
Protein Pathways | Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway |
Documents
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