CD130 (IL6ST) Mouse Monoclonal Antibody [Clone ID: B-T2]

CAT#: SM2115P

CD130 (IL6ST) mouse monoclonal antibody, clone B-T2, Purified

Specifications

Product Data

• Clone Name: B-T2
• Applications: ELISA, FC
• Recommended Dilution: ELISA.
  Flow Cytometry: 0.2µg/10⁶cells; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Natural soluble gp130 receptor. Spleen cells from immunised BALB/c (Iffa Credo) mice were fused with cells of the X63.Ag8.653 mouse myeloma cell line.
• Specificity: This antibody specifically recognises soluble and membrane bound gp130 receptor. This antibody has been reported to block the activity of IL-6.
• Formulation: PBS containing 0.09% Sodium Azide
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: Ion exchange chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch
• Database Link:
  Entrez Gene 3572 Human
• Background: CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
• Synonyms: Interleukin-6 receptor subunit beta, IL-6R-beta, IL6 receptor beta