Il1r1 (Extracell. Dom.) Hamster Monoclonal Antibody [Clone ID: JAMA-147]

CAT#: SM2246PS

Il1r1 (Extracell. Dom.) hamster monoclonal antibody, clone JAMA-147, Purified

Specifications

Product Data

• Clone Name: JAMA-147
• Applications: FC, IP
• Recommended Dilution: Flow Cytometry: Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
  Immunoprecipitation.
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Extracellular domain of murine IL-1R.
  Spleen cells from immunised Armenian Hamster were fused with cells of the mouse P3X63.Ag 8-653 myeloma cell line.
• Specificity: This antibody recognises CD121a, which is the 80kD type I interleukin-1 receptor. Clone JAMA-147 has been reported to block IL-1 dependent cellular responses.
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction.
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography on Protein G
• Gene Name: interleukin 1 receptor, type I
• Database Link:
  Entrez Gene 16177 Mouse
• Background: CD121a is weakly expressed on most cells and tissues including T lymphocytes, thymocytes, epithelial cells and dendritic cells, with stronger expression reported on fibroblasts. The ligands for CD121a are the interleukin-1 (IL-1) family members; IL-1 alpha; IL-1 beta and IL-1 receptor antagonist. IL-1 is a mediator of inflammation and can elicit a variety of other biological responses through binding to CD121a.
• Synonyms: IL1R, IL1RA, IL1RT1, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type 1