CD41-CD61 Complex Mouse Monoclonal Antibody [Clone ID: IVA30]

CAT#: SM3022P

CD41-CD61 Complex mouse monoclonal antibody, clone IVA30, Aff - Purified

Specifications

Product Data

• Clone Name: IVA30
• Applications: ELISA, FC, IHC, IP
• Recommended Dilution: Flow Cytometry.
  Immunoprecipitation.
  Immunohistochemistry on Frozen Sections.
  ELISA.
• Reactivities: Bovine
• Host: Mouse
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Bovine trombocytes
• Specificity: The antibody reacts with CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage.
• Formulation: Phosphate buffered saline (PBS) with 15 mM Sodium Azide as preservative, approx. pH 7.4.
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography on Protein A .
• Background: CD41 is a transmembrane glycoprotein (integrin family) composed of two chains GPIIba (heavy chain; 120 kDa) and GPIIbb (light chain; 23 kDa). CD61 non-covalently associates
  with CD41.
  CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes; the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT).
• Synonyms: GPIIb-IIIa, ITGA2B, GP2B, ITGAB, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, GP3A, CD41, CD61, Integrin alpha-IIb, Integrin beta-3, ITGB3