CD1 (CD1A) Mouse Monoclonal Antibody [Clone ID: HI149]

CAT#: SM3086P

CD1 (CD1A) mouse monoclonal antibody, clone HI149, Purified

Specifications

Product Data

• Clone Name: HI149
• Applications: FC, IHC
• Recommended Dilution: Flow cytometry.
  Immunohistochemistry on frozen sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human thymocytes
• Specificity: The antibody reacts with CD1a (T6), a 49 KDa polypeptide associated with b2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas.
  The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
  State: Purified
  State: Liquid Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Protein G-affinity chromatography; purity: > 95% (by SDS-PAGE)
• Gene Name: CD1a molecule
• Database Link:
  Entrez Gene 909 Human
• Background: CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
• Synonyms: T6/Leu-6, hTa1