DR4 (TNFRSF10A) Mouse Monoclonal Antibody [Clone ID: DR-4-02]

CAT#: SM3131R

DR4 (TNFRSF10A) mouse monoclonal antibody, clone DR-4-02, PE

Product Images

Surface staining of CD261-transfected HEK-293 cells with anti-CD261/TRAIL-R1 (DR-4-02) PE.

Specifications

Product Data

• Clone Name: DR-4-02
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis: 5 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the Human IgG1.
• Specificity: The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a Human Death Receptor 4 (468 amino acids) expressed in most Human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
• Formulation: PBS containing 15 mM sodium azide as preservative and 0.2% (w/v) high-grade BSA (Protease free) as stabilizer.
  Label: PE
  State: Liquid purified IgG fraction.
  Label: Conjugated with R-Phycoerythrin under optimum conditions
• Concentration: 0.1 mg/ml
• Purification: Size-Exclusion Chromatography.
• Conjugation: PE
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 10a (TNFRSF10A)
• Database Link:
  Entrez Gene 8797 Human
• Background: TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues.
  Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
• Synonyms: APO2, DR4, Death receptor 4, TRAIL receptor 1, TRAIL-R1, TNFRSF10A

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity