CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: HIP2]

CAT#: SM3144P

CD41 (ITGA2B) mouse monoclonal antibody, clone HIP2, Purified

Specifications

Product Data

• Clone Name: HIP2
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry (Has been tested by flow cytometric analysis of human platelets. Can be used at less than or equal to 1 µg per 100 µl blood.
  Immunohistochemistry (frozen sections).
• Reactivities: Human, Primate
• Host: Mouse
• Isotype: IgG3
• Clonality: Monoclonal
• Specificity: The antibody reacts with beta (b) subunit of CD41 glycoprotein (light chain; 23 kDa).
  CD41 is mainly expressed on platelets and megakaryocytes.
• Formulation: Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
  State: Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Purified by protein A; purity: > 95 % (by SDS-PAGE)
• Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit alpha 2b
• Database Link:
  Entrez Gene 3674 Human
• Background: CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, a and 23 kDa b, b) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
• Synonyms: Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb