Von Willebrand Factor (VWF) Sheep Polyclonal Antibody

CAT#: SP1313F

Von Willebrand Factor (VWF) sheep polyclonal antibody, FITC, Purified

Specifications

Product Data

• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry: Membrane permeabilisation is required.
  Immunohistochemistry on Frozen Sections: 1/50-1/100.
  Recommended Positive Control: Tonsil.
• Reactivities: Human
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Purified Human von Willebrand factor.
• Specificity: This antibody recognizes Human von Willebrand factor. Other species not tested.
• Formulation: PBS
  Label: FITC
  State: Purified
  State: Liquid purified IgG fraction from Serum
  Preservative: 0.09% Sodium Azide
  Label: Fluorescein Isothiocyanate Isomer 1
• Purification: Ion Exchange Chromatography
• Conjugation: FITC
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  This product is photosensitive and should be protected from light.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 7450 Human
• Background: Von Willebrand Factor (VWF) was previously known as Factor VIII related antigenis. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).
• Synonyms: vWF, von Willebrand antigen 2, von Willebrand antigen II, F8VWF, Factor VIII Related Antigen