IDO1 Sheep Polyclonal Antibody

CAT#: SP1516P

IDO1 sheep polyclonal antibody, Ig Fraction

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/1000.
  Immunohistochemistry on Paraffin Sections: This antibody requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.
  Does not work on Frozen Sections.
• Reactivities: Human
• Host: Sheep
• Clonality: Polyclonal
• Immunogen: Recombinant human indoleamine 2,3-dioxygenase.
• Specificity: This antibody recognises Indoleamine 2,3-Dioxygenase (IDO), an enzyme that is responsible for converting tryptophan to kynurenines.
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative.
  State: Ig Fraction
  State: Liquid Ig fraction.
• Concentration: lot specific
• Purification: Ammonium Sulphate Precipitation
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 3620 Human
• Background: IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. Reports suggest that IDO is involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.
• Synonyms: IDO1, IDO, INDO, Indoleamine 2,3-dioxygenase 1, EC=1.13.11.52, Indoleamine 2,3-dioxygenase, IDO, Indoleamine-pyrrole 2,3-dioxygenase