APPBP1 (NAE1) Rabbit Polyclonal Antibody

CAT#: TA300061

APPBP1 rabbit polyclonal  antibody

Product Images

Western blot analysis of anti-APPBP1 Antibody (C-term) (Cat.#TA300061) in mouse brain tissue lysates (35ug/lane). APPBP1 (arrow) was detected using the purified Pab.

• 

  Western blot analysis of APP-BP1 (arrow) using rabbit polyclonal APP-BP1 Antibody (C-term) (Cat.#TA300061). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APP-BP1 gene (Lane 2) (Origene Technologies).

• 

  Formalin-fixed and paraffin-embedded human breast carcinoma reacted with anti-APPBP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:50~100
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: This NAE1 (APPBP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-459 amino acids from the C-terminal region of human NAE1 (APPBP1).
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Concentration: lot specific
• Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NEDD8 activating enzyme E1 subunit 1
• Database Link:
  NP_001018169
  Entrez Gene 84019 RatEntrez Gene 234664 MouseEntrez Gene 696429 MonkeyEntrez Gene 8883 Human
  UniProt ID Q13564
• Background: APPBP1 binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPB1 is required for cell cycle progression through the S/M checkpoint.
• Synonyms: A-116A10.1; APPBP1; HPP1; ula-1

Reference Data

• Protein Pathways: Alzheimer's disease