MEK4 (MAP2K4) Rabbit Monoclonal Antibody [Clone ID: EP615Y]
Other products for "MAP2K4"
Specifications
Product Data | |
Clone Name | EP615Y |
Applications | FC, IHC, WB |
Recommended Dilution | WB: 1:1000; FC: 1:1000 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | A synthetic peptide corresponding to residues in the C-term of human MKK4 was used as immunogen. |
Formulation | PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 44 kDa |
Gene Name | mitogen-activated protein kinase kinase 4 |
Database Link | |
Background | MKK4, also known as JNKK1 and SEK1, is a dual specificity kinase that belongs to the Ser/Thr protein kinase family. MKK4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MKK4 phosphorylate and activate p38 MAP kinase and JNK but not ERK 1/2 (1-2). JNK is activated by dual phosphorylation at Thr and Tyr by MKK4 and MKK7; although MKK4 will preferentially phosphorylate Tyr (3). MKK4 is also known to be a tumor suppressor, as mutations inactivating the MKK4 gene have been found in 5% of a wide variety of tumor types (4). |
Synonyms | JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1 |
Note | Is unsuitable for ICC or IP. |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Toll-like receptor signaling pathway |
Documents
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