S100A12 Rabbit Polyclonal Antibody
Frequently bought together (3)
Recombinant protein of human S100 calcium binding protein A12 (S100A12)
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Transient overexpression lysate of S100 calcium binding protein A12 (S100A12)
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Other products for "S100A12"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Immunocytochemistry/ Immunofluorescence: 1:500, Western Blot: 1:1000 |
Reactivities | Human (Does not react with: Mouse, Rat) |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Full length human S100A12 protein [Swiss-Prot# P80511] expressed in E. coli. |
Formulation | 0.1% sodium azide |
Purification | Whole antisera |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | S100 calcium binding protein A12 |
Database Link | |
Background | S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties. |
Synonyms | CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6 |
Reference Data |
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