DERL1 Rabbit Polyclonal Antibody

CAT#: TA301554

Rabbit Polyclonal Antibody against Derlin-1

Product Images

Western Blot: Derlin 1 Antibody TA301554 - Detection of Derlin protein in canine KRM microsomes.

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  Immunocytochemistry/Immunofluorescence: Derlin 1 Antibody TA301554 - Derlin-1 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

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  Immunohistochemistry: Derlin 1 Antibody TA301554 - Staining of human liver.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry: 5-10 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:2000, Western Blot: 1:1000-1:5000, Immunohistochemistry-Paraffin: 5-10 ug/ml
• Reactivities: Human, Dog
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to the C-terminal region of the human Derlin-1 protein sequence (between residues 200-251).
• Formulation: Tris-citrate/phosphate, pH 7-8, 0.1% sodium Azide
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: derlin 1
• Database Link:
  NP_077271
  Entrez Gene 475086 DogEntrez Gene 79139 Human
  UniProt ID Q9BUN8
• Background: Derlin-1 is a channel-like protein, found in the ER membrane, responsible for degrading and funneling misfolded proteins and other cellular debris into the appropriate degradative pathways within the cell.
• Synonyms: DER-1; DER1; derlin-1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS)