LINGO1 Rabbit Polyclonal Antibody

CAT#: TA302273

Rabbit Polyclonal Antibody against LINGO1 (N-term)

Product Images

Western blot analysis of LINGO1 (arrow) using rabbit polyclonal LINGO1 Antibody (N-term) (Cat.#TA302273).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LINGO1 gene (Lane 2) (Origene Technologies).

• 

  Formalin-fixed and paraffin-embedded human brain tissue reacted with LINGO1 Antibody (N-term) (Cat.#TA302273), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:10~50
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This LINGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-92 amino acids from the N-terminal region of human LINGO1.
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Concentration: lot specific
• Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 69876 Da
• Gene Name: leucine rich repeat and Ig domain containing 1
• Database Link:
  NP_116197
  Entrez Gene 235402 MouseEntrez Gene 714985 MonkeyEntrez Gene 84894 Human
  UniProt ID Q96FE5
• Background: LINGO1 is a functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
• Synonyms: LERN1; LRRN6A; UNQ201

Reference Data

• Protein Families: Druggable Genome, Transmembrane