APPL (APPL1) Goat Polyclonal Antibody

CAT#: TA302413

Goat Polyclonal Antibody against APPL1

Product Images

TA302413 (0.5ug/ml) staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL1 adenovirus for 48hrs. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:64,000. WB: 0.3-1µg/ml.
• Reactivities: Expected from seq similarity: Human, Mouse, Rat, Dog, Cow
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-NRYSRLSKKRENDK, from the internal region of the protein sequence according to NP_036228.1.
• Formulation: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 83295 Da
• Gene Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
• Database Link:
  NP_036228
  Entrez Gene 72993 MouseEntrez Gene 290537 RatEntrez Gene 484716 DogEntrez Gene 26060 Human
  UniProt ID Q9UKG1
• Background: The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq]
• Synonyms: APPL; DIP13alpha; MODY14

Reference Data

• Protein Pathways: Colorectal cancer, Pathways in cancer