Cbl Goat Polyclonal Antibody

CAT#: TA302756

Goat Polyclonal Antibody against CBL

Product Images

TA302756 staining (2ug/ml) of 3T3 lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1-3µg/ml.
• Reactivities: Mouse
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-REFVSISSPAHVAT, from the C Terminus of the protein sequence according to NP_005179.2.
• Formulation: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Casitas B-lineage lymphoma
• Database Link:
  NP_031645
  Entrez Gene 867 HumanEntrez Gene 500985 RatEntrez Gene 489369 DogEntrez Gene 12402 Mouse
  UniProt ID P22682
• Background: The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq]
• Synonyms: C-CBL; CBL2; RNF55