Acinus (ACIN1) Rabbit Polyclonal Antibody

CAT#: TA306020

Rabbit Polyclonal Acinus Antibody

Product Images

Western blot analysis of Acinus in K562 whole cell lysate with Acinus antibody (IN) at 1ug/ml.

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  Immunofluorescence of Acinus in K562 cells with Acinus antibody at 20ug/ml.

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  Immunofluorescence of Acinus in K562 cells with Acinus antibody at 20ug/ml.

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  Immunofluorescence of Acinus in K562 cells with Acinus antibody at 20ug/ml.

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  Immunocytochemistry of Acinus in K562 cells with Acinus antibody at 5ug/ml.

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Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Acinus antibody was raised against a 35 amino acid peptide near the center of human Acinus. The immunogen is located within amino acids 760 - 810 of Acinus.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: apoptotic chromatin condensation inducer 1
• Database Link:
  NP_001158286
  Entrez Gene 22985 Human
  UniProt ID Q9UKV3
• Background: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE . A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS’ (2).
• Synonyms: ACINUS; ACN; fSAP152

Reference Data

• Protein Pathways: Spliceosome