CARD15 (NOD2) Rabbit Polyclonal Antibody

CAT#: TA306092

Rabbit Polyclonal NOD2 Antibody


USD 430.00

In Stock*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 2 - 4 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Rabbit NOD2 polyclonal antibody was raised against a synthetic peptide corresponding to 14 amino acids at the carboxy terminus of human NOD2.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Immunoaffinity chromatography purified IgG
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name nucleotide binding oligomerization domain containing 2
Background Apaf-1 and NOD1 are members of a new family (1), which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2 (2). NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kappaB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn’s disease (3,4) that is a main type of chronic inflammatory bowel disease.
Synonyms ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1
Reference Data
Protein Families Druggable Genome
Protein Pathways NOD-like receptor signaling pathway

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