TRIF (TICAM1) Rabbit Polyclonal Antibody

CAT#: TA306137

Rabbit Polyclonal TRIF Antibody

Product Images

Western blot analysis of TRIF in human lung cell lysates with TRIF antibody at (A) 2 and (B) 4 ug/ml.

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  Immunohistochemistry of TRIF in human lung tissue with TRIF antibody at 10 ug/ml.

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  Immunofluorescence of TRIF in Human Lung cells with TRIF antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 2 - 4 ug/mL, ICC: 10 ug/mL, IF: 10 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRIF antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human TRIF.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor adaptor molecule 1
• Database Link:
  NP_055076
  Entrez Gene 148022 Human
  UniProt ID Q8IUC6
• Background: TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TRIF engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3 (5). TRIF is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-?B (6).
• Synonyms: MGC35334; PRVTIRB; TICAM-1; TIR domain-containing adaptor molecule 1; TIR domain containing adaptor inducing interferon-beta; toll-like receptor adaptor molecule 1; TRIF

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Toll-like receptor signaling pathway