Bim (BCL2L11) Rabbit Polyclonal Antibody

CAT#: TA306192

Rabbit Polyclonal Bim Antibody

Product Images

Western blot analysis of Bim in K562 cell lysates with Bim antibody (IN2) at (A) 2.5 and (B) 5 ug/mL.

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  Immunocytochemistry of BIM in K562 cells with Bim antibody at 10 ug/mL.

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  Immunocyochemistry of BIM in K562 cells with Bim antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 2.5 - 5 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Bim antibody was raised against a peptide corresponding to amino acids near the center of human Bim The sequence is identical to that of mouse and rat.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: BCL2 like 11
• Database Link:
  NP_006529
  Entrez Gene 12125 MouseEntrez Gene 64547 RatEntrez Gene 10018 Human
  UniProt ID O43521
• Background: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1,2).
• Synonyms: BAM; BIM; BOD

Reference Data

• Protein Families: Druggable Genome