LAMP1 Rabbit Polyclonal Antibody

CAT#: TA306262

Rabbit Polyclonal LAMP-1 Antibody

Product Images

Western blot analysis of LAMP-1 in EL4 cell lysate with LAMP-1 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of LAMP-1 in human colon tissue with LAMP-1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 20 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lysosomal associated membrane protein 1
• Database Link:
  NP_005552
  Entrez Gene 16783 MouseEntrez Gene 25328 RatEntrez Gene 3916 Human
  UniProt ID P11279
• Background: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome (4,5). LAMP-1 shares much homology to LAMP-2 and is thought to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression (6). However, the loss of both proteins resulted in embryonic lethality (7), suggesting that each protein possesses some unique and necessary functions.
• Synonyms: CD107a; LAMPA; LGP120

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Lysosome