TIM 4 (TIMD4) Rabbit Polyclonal Antibody

CAT#: TA306323

Rabbit Polyclonal TIM-4 Antibody

Product Images

Western blot analysis of TIM-4 in RAW264.7 cell lysate with TIM-4 antibody at 2ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of TIM-4 in human spleen tissue with TIM-4 antibody at 2.5ug/ml.

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  Immunohistochemistry of TIM-4 in mouse liver tissue with TIM-4 antibody at 2ug/ml.

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  Immunofluorescence of TIM-4 in Jurkat cells with TIM-4 antibody at 20ug/ml.

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  Immunofluorescence of TIM-4 in human spleen tissue with TIM-4 antibody at 20ug/ml.

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  Immunocytochemistry of TIM-4 in Jurkat cells with TIM-4 antibody at 10ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TIM-4 antibody was raised against a 16 amino acid synthetic peptide from near the center of human TIM-4. The immunogen is located within amino acids 60 - 110 of TIM-4.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: T-cell immunoglobulin and mucin domain containing 4
• Database Link:
  NP_001140198
  Entrez Gene 276891 MouseEntrez Gene 91937 Human
  UniProt ID Q96H15
• Background: The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
• Synonyms: SMUCKLER; TIM4

Reference Data

• Protein Families: Druggable Genome, Transmembrane