PKR (EIF2AK2) Rabbit Polyclonal Antibody

CAT#: TA306357

Rabbit Polyclonal PKR Antibody


USD 430.00

2 Weeks*

Size
    • 100 ug

Product Images

Other products for "EIF2AK2"

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL, ICC: 5 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen PKR antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human PKR.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name eukaryotic translation initiation factor 2 alpha kinase 2
Background The interferon-inducible, double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family, possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system. Upon binding dsRNA, PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2, resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
Synonyms EIF2AK1; PKR; PPP1R83; PRKR
Reference Data
Protein Families Druggable Genome, Protein Kinase, Transcription Factors

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.