CRLF2 Rabbit Polyclonal Antibody

CAT#: TA306426

Rabbit Polyclonal TSLP Receptor Antibody

Product Images

Western blot analysis of TSLP Receptor in human liver tissue lysate with TSLP Receptor antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

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  Immunohistochemistry of TSLP-R in human liver tissue with TSLP-R antibody at 5 ug/ml.

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  Immunofluorescence of TSLP Receptor in Human Liver tissue with TSLP Receptor antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TSLP Receptor antibody was raised against a 19 amino acid peptide from near the center of human TSLP receptor.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cytokine receptor-like factor 2
• Database Link:
  NP_001012288
  Entrez Gene 64109 Human
  UniProt ID Q9HC73
• Background: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE.
• Synonyms: CRL2; CRLF2Y; TSLPR

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway