Crlf2 Rabbit Polyclonal Antibody

CAT#: TA306427

Rabbit Polyclonal TSLP Receptor Antibody

Product Images

Western blot analysis of TSLP Receptor in mouse heart tissue lysate with TSLP Receptor antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.

• 

  Immunofluorescence of TSLP Receptor in Mouse Liver cells with TSLP Receptor antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TSLP receptor antibody was raised against a 21 amino acid peptide from near the center of mouse TSLP receptor.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cytokine receptor-like factor 2
• Database Link:
  NP_057924
  Entrez Gene 57914 Mouse
  UniProt ID Q8CII9
• Background: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.
• Synonyms: CRL2; CRLF2Y; IL-XR; ILXR; TSLPR