RAP80 (UIMC1) Rabbit Polyclonal Antibody
Other products for "UIMC1"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | WB: 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | RAP80 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human RAP80. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | ubiquitin interaction motif containing 1 |
Database Link | |
Background | RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist. |
Synonyms | RAP80; X2HRIP110 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Documents
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