GPR124 (ADGRA2) Rabbit Polyclonal Antibody

CAT#: TA306488

Rabbit Polyclonal TEM5 Antibody

Product Images

Western blot analysis of TEM5 in human bladder tissue lysate with TEM5 antibody at (A) 2 and (B) 4 ug/ml.

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  Immunohistochemistry of TEM5 in human bladder tissue with TEM5 antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 2 - 4 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TEM5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human TEM5.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: adhesion G protein-coupled receptor A2
• Database Link:
  NP_116166
  Entrez Gene 100363275 RatEntrez Gene 25960 Human
  UniProt ID Q96PE1
• Background: Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
• Synonyms: GPR124; TEM5

Reference Data

• Protein Families: Druggable Genome, Transmembrane