GRIK5 Rabbit Polyclonal Antibody

CAT#: TA306500

Rabbit Polyclonal Grik5 Antibody

Product Images

Western blot analysis of Grik5 in human brain tissue lysate with Grik5 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

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  Immunohistochemical staining of human brain tissue using Grik5 antibody at 2.5 ug/ml.

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  Immunofluorescence of Grik5 in Human Brain cells with Grik5 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Grik5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human Grik5.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: glutamate ionotropic receptor kainate type subunit 5
• Database Link:
  NP_002079
  Entrez Gene 14809 MouseEntrez Gene 24407 RatEntrez Gene 2901 Human
  UniProt ID Q16478
• Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface. This Grik5 antibody does not cross-react with Grik4.
• Synonyms: EAA2; GluK5; GRIK2; KA2

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction