Glycoprotein VI (GP6) Rabbit Polyclonal Antibody

CAT#: TA306632

Rabbit Polyclonal GPVI Antibody

Product Images

Western blot analysis of GPVI in A20 lysate with GPVI antibody at 1ug/ml in either the absence or (B) the presence of blocking peptide.

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  Immunohistochemistry of GPVI in human heart tissue with GPVI antibody at 10 ug/ml.

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  Immunofluorescence of GPVI in Human Heart tissue with GPVI antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GPVI antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPVI.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: glycoprotein VI platelet
• Database Link:
  NP_001077368
  Entrez Gene 243816 MouseEntrez Gene 684555 RatEntrez Gene 51206 Human
  UniProt ID Q9HCN6
• Background: Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcR?) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR?, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.
• Synonyms: BDPLT11; GPIV; GPVI

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ECM-receptor interaction