PRTFDC1 Rabbit Polyclonal Antibody

CAT#: TA306634

Rabbit Polyclonal PRTFDC1 Antibody

Product Images

Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PRTFDC1 antibody was raised against a 14 amino acid peptide from near the center of human PRTFDC1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: phosphoribosyl transferase domain containing 1
• Database Link:
  NP_064585
  Entrez Gene 291355 RatEntrez Gene 56952 Human
  UniProt ID Q9NRG1
• Background: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
• Synonyms: HHGP

Reference Data

• Protein Families: Druggable Genome