SPRED1 Rabbit Polyclonal Antibody

CAT#: TA306657

Rabbit Polyclonal Spred1 Antibody

Product Images

Western blot analysis of Spred1 in mouse brain tissue lysate with Spred1 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of Spred1 in human brain tissue with Spred1 antibody at 2.5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Spred1 antibody was raised against a 20 amino acid peptide near the center of the human Spred1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sprouty related EVH1 domain containing 1
• Database Link:
  NP_689807
  Entrez Gene 114715 MouseEntrez Gene 296072 RatEntrez Gene 161742 Human
  UniProt ID Q7Z699
• Background: The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3.
• Synonyms: hSpred1; NFLS; PPP1R147; spred-1

Reference Data

• Protein Pathways: Jak-STAT signaling pathway