PDCD5 Rabbit Polyclonal Antibody

CAT#: TA306721

Rabbit Polyclonal PDCD5 Antibody

Product Images

Western blot analysis of PDCD5 in EL4 cell lysate with PDCD5 antibody at 1ug/mL.

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  Immunocytochemistry of PDCD5 in Jurkat cells with PDCD5 antibody at 2 ug/mL.

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  Immunofluorescence of PDCD5 in Jurkat cells with PDCD5 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PDCD5 antibody was raised against a 21 amino acid peptide from near the carboxy terminus of human PDCD5.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: programmed cell death 5
• Database Link:
  NP_004699
  Entrez Gene 56330 MouseEntrez Gene 292814 RatEntrez Gene 9141 Human
  UniProt ID O14737
• Background: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
• Synonyms: TFAR19