SYPL2 Rabbit Polyclonal Antibody

CAT#: TA306804

Rabbit Polyclonal SYPL2 Antibody

Product Images

Western blot analysis of SYPL2 in human spleen tissue lysate with SYPL2 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of SYPL2 in human spleen tissue with SYPL2 antibody at 2.5 ug/ml.

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  Immunofluorescence of SYPL2 in Human Spleen cells with SYPL2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SYPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human SYPL.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: synaptophysin like 2
• Database Link:
  NP_001006604
  Entrez Gene 17306 MouseEntrez Gene 362018 RatEntrez Gene 284612 Human
  UniProt ID Q5VXT5
• Background: SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.
• Synonyms: MG29; mitsugumin-29; mitsugumin 29; OTTHUMP00000012638; synaptophysin-like 2

Reference Data

• Protein Families: Transmembrane