Cyclin T2 (CCNT2) Rabbit Polyclonal Antibody

CAT#: TA307981

Rabbit polyclonal antibody to cyclin T2 (cyclin T2)

Product Images

Sample (30 ug of whole cell lysate). A: Hep G2. 7.5% SDS PAGE. TA307981 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded H1299 Xenograft, using cyclin T2 (TA307981) antibody at 1:100 dilution.

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  Immunofluorescence analysis of paraformaldehyde-fixed A431, using cyclin T2 (TA307981) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 497 and 730 of cyclin T2 (Uniprot ID#O60583)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 81 kDa
• Gene Name: cyclin T2
• Database Link:
  NP_490595
  Entrez Gene 72949 MouseEntrez Gene 304758 RatEntrez Gene 905 Human
  UniProt ID O60583
• Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described. [provided by RefSeq]
• Synonyms: CYCT2
• Note: Seq homology of immunogen across species: Mouse (80%), Rat (80%), Bovine (95%)

Reference Data

• Protein Families: Druggable Genome, Transcription Factors