PMM2 Rabbit Polyclonal Antibody

CAT#: TA308120

Rabbit Polyclonal antibody to PMM2 (phosphomannomutase 2)

Product Images

Sample (30 ug of whole cell lysate). A: Hela. B: Hep G2. 12% SDS PAGE. TA308120 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded U87 xenograft, using PMM2 (TA308120) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 214 of PMM2 (Uniprot ID#O15305)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 28 kDa
• Gene Name: phosphomannomutase 2
• Database Link:
  NP_000294
  Entrez Gene 54128 MouseEntrez Gene 302915 RatEntrez Gene 5373 Human
  UniProt ID O15305
• Background: The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq]
• Synonyms: CDG1; CDG1a; CDGS; PMI; PMI1; PMM 2
• Note: Seq homology of immunogen across species: Mouse (93%), Chicken (86%), Rat (95%), Bovine (93%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism, Metabolic pathways