GBA Rabbit Polyclonal Antibody

CAT#: TA308240

Rabbit Polyclonal antibody to GBA (glucosidase, beta, acid)

Product Images

Sample (30 ug of whole cell lysate). A:Hep G2. 7.5% SDS PAGE. TA308240 diluted at 1:500

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  Immunohistochemical analysis of paraffin-embedded Lung CA, using GBA (TA308240) antibody at 1:100 dilution.

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  Immunofluorescence analysis of methanol-fixed HeLa, using GBA (TA308240) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 352 and 536 of GBA (Uniprot ID#P04062)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 60 kDa
• Gene Name: glucosylceramidase beta
• Database Link:
  NP_001005750
  Entrez Gene 2629 Human
  UniProt ID P04062
• Background: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]
• Synonyms: acid (includes glucosylceramidase); beta; D-glucosyl-N-acylsphingosine glucohydrolase; GBA1; GCB; GLUC; glucocerebrosidase; glucocerebrosidase (alt.); glucosidase; lysosomal glucocerebrosidase; OTTHUMP00000033992; OTTHUMP00000033993
• Note: Seq homology of immunogen across species: Chimpanzee (100%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism