TRADD Rabbit Polyclonal Antibody

CAT#: TA308445

Rabbit Polyclonal antibody to TRADD (TNFRSF1A-associated via death domain)

Product Images

Sample (10 ug of whole cell lysate). A: A549. B: SiHa. 10% SDS PAGE. TA308445 diluted at 1:1000.

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  TRADD antibody [N1], N-term detects TRADD protein at cytosol on colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. TRADD antibody [N1], N-term (TA308445) dilution: 1:500.

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  Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using TRADD (TA308445) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with anti-alpha tubulin antibody (Red) at 1:2000.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 1 and 43 of TRADD (Uniprot ID#Q15628)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 34 kDa
• Gene Name: TNFRSF1A associated via death domain
• Database Link:
  NP_003780
  Entrez Gene 71609 MouseEntrez Gene 246756 RatEntrez Gene 8717 Human
• Background: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq]
• Synonyms: Hs.89862
• Note: Seq homology of immunogen across species: Mouse (100%), Rat (92%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Apoptosis, RIG-I-like receptor signaling pathway