DHH Rabbit Polyclonal Antibody

CAT#: TA308606

Rabbit polyclonal antibody to Dhh (desert hedgehog homolog (Drosophila))

Product Images

Sample (30 ug of whole cell lysate). A: A431. 10% SDS PAGE. TA308606 diluted at 1:10000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:5000-1:20000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 135 and 396 of Dhh (Uniprot ID#O43323)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 44 kDa
• Gene Name: desert hedgehog
• Database Link:
  NP_066382
  Entrez Gene 13363 MouseEntrez Gene 84380 RatEntrez Gene 50846 Human
  UniProt ID O43323
• Background: This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq]
• Synonyms: GDXYM; HHG-3; SRXY7
• Note: Seq homology of immunogen across species: Mouse (98%), Rat (98%)

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protease
• Protein Pathways: Hedgehog signaling pathway