C5L2 (C5AR2) Rabbit Polyclonal Antibody

CAT#: TA308708

Rabbit polyclonal antibody to GPR77 (G protein-coupled receptor 77)

Product Images

Sample (30 ug of whole cell lysate). A: HeLa. B: Molt-4. 10% SDS PAGE. TA308708 diluted at 1:1000

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 248 and 337 of GPR77 (Uniprot ID#Q9P296)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 36 kDa
• Gene Name: complement component 5a receptor 2
• Database Link:
  NP_060955
  Entrez Gene 27202 Human
  UniProt ID Q9P296
• Background: The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]). [supplied by OMIM]
• Synonyms: C5L2; GPF77; GPR77
• Note: Seq homology of immunogen across species: Bovine (86%)

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane